Novak Djokovic departs the Park Hotel while under immigration detention. | Reuters

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Novak Djokovic was set to be deported from Australia after a court on Sunday dismissed his appeal against the government's cancellation of his Australian visa on the grounds that his decision not to be vaccinated posed a risk to the country.

Djokovic had appealed Immigration Minister Alex Hawke's use of discretionary powers to cancel his visa on the grounds that he was a threat to public order because his presence would encourage anti-vaccination sentiment amidst Australia's worst outbreak of the virus.

Chief Justice James Allsop said the Federal Court ruling was based on the lawfulness and legality of the minister's decision in the context of the three grounds of appeal Djokovic's team lodged.

"It is no part of the function of the court to decide upon the merits or wisdom of the decision," Allsop said, adding the decision was unanimous among the three judges. Full reasoning behind the decision would be released in coming days, he said.

It was not immediately clear when the government would seek to remove Djokovic.

The verdict brings to a climax a rollercoaster ten days during the world's top tennis player was detained by immigration authorities, released and then detained again ahead of the tournament that starts on Monday.