The Russian will now seek to stop Nadal from setting an all-time men's record of 21 Grand Slam titles.
Nadal will contest his 36th Grand Slam semi-final on Friday.
Rafa Nadal has drawn within two wins of a record 21st Grand Slam title.
The vacant spot in the draw will be decided after qualifying.
Nadal said what has been happening was not good for anyone.
Spain's Rafael Nadal in action during his quarter final match against Greece's Stefanos Tsitsipas.
The 20-times Grand Slam champion took to the John Cain Arena court in the late afternoon
The Spaniard was one of the top players who quarantined in Adelaide for 14 days after their arrival Down Unde.
Nadal would hope he would be fit to play the tie and get some match practice before the Feb. 8-21 Australian Open.
Nadal kicks off his season against Australia's Alex de Minaur in an ATP Cup Group B singles match on Rod Laver Arena on Tuesday.
Majorca's Rafa Nadal in action against Austrian Dominic Thiem during an event in Adelaide on Friday.
The start of this year's tournament has been pushed back by a day to allow more time to train for 72 players confined to their hotel rooms.